It suddenly happened that whenever I tried to open an Excel file(.xlsx), I always received the following error message:

“There was a problem sending the command to the program”

Excel just opened itself without opening the actual xlsx file, which was very annoying.

I finally came to the solution:  Open the Microsoft Office program and open its Options window.in Advanced tab un-check “Ignore other applications that use Dynamic Data Exchange (DDE)” option and restart Excel.

 

Below is the link I followed(solution 1 fixed my problem)

[Fix] “There was a Problem Sending the Command to the Program” Error Message in Windows

 

Excel There was a problem sending the command to the program

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